Glucose 1-dehydrogenase
| glucose 1-dehydrogenase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 1.1.1.47 | ||||||
| CAS number | 9028-53-9 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction
- beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
The 3 substrates of this enzyme are beta-D-glucose, NAD+, and NADP+, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Other names in common use include D-glucose dehydrogenase (NAD(P)+), and hexose phosphate dehydrogenase. This enzyme participates in pentose phosphate pathway.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1G6K, 1GCO, 1GEE, 1RWB, 1SPX, 2B5V, 2B5W, 2CD9, and 2CDA.
References
- K, Rick W, Staudinger HJ (1975). "[A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)]". Z. Klin. Chem. Klin. Biochem. 13 (3): 101–7. PMID 810982.
- Brink NG; Miettinen, Jorma K.; Olsen, John; Virtanen, Artturi I.; Sörensen, Nils Andreas (1953). "Beef liver glucose dehydrogenase. 1. Purification and properties". Acta Chem. Scand. 7: 1081–1089. doi:10.3891/acta.chem.scand.07-1081.
- Pauly HE and Pfleiderer G (1976). "D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure". Hoppe-Seyler's Z. Physiol. Chem. 356 (10): 1613–1623. PMID 2530.
- STRECKER HJ, KORKES S (1952). "Glucose dehydrogenase". J. Biol. Chem. 196 (2): 769–84. PMID 12981017.
- Thompson RE, Carper WR (1970). "Glucose dehydrogenase from pig liver. I. Isolation and purification". Biochim. Biophys. Acta. 198 (3): 397–406. PMID 4392298.